Endocrine Abstracts

We have shown that Type I IFN paradoxically inhibits autoimmune diabetes in the NOD mouse and BB rat. We assessed the structure function relationship and potential mechanism of this interferon action by determining: (1) the diabetes sparing effect of several type 1 IFNs: recombinant human IFN-A/D bgl 11 (rIFN-alpha), rIFN-alphaB/D, rIFN-alpha-consensus (CIFN), IFN-taumod1 in NOD mice (2) the effect of IFN-tau administration in IL-4 KO and IFN-gamma KO NOD mice (3) the effect o...

Although, high doses of cyclosporine (cyclo)has been demonstrated to inhibit the development of type 1diabetes mellitus (T1D), its usefulness was limited by its toxicity. Since methotrexate (Mtx) and cyclo have been shown to synergistically act in other disease processes, we determined if low dose cyclo and Mtx therapy could inhibit the development of diabetes and reduce or eliminate the need for insulin therapy in a pilot study.Methods: Insulin dose and...